Biologically ...not really. Socially it is frowned upon and borderline illegal.
There is a metric that is generally the acceptable age difference, and that is
Half the age plus 7.
...so 33/2=16.5 + 7 = 23.5
A 33 year old should be going out with no younger than a 23 year old.
in your case the upper end should be 19.
Aside from that the two of you should be in different stages of life and the compatibility for a proper relationship is minimal.
I am a dude and when I was 19 I went out with a 33 year old woman and the sex was hot. We were in our sexual primes (18 for men vs. 30 for women)
Biologically a girl of 16 is attracted to older more established men (power, stability) so that any offspring will be taken care of and have a good chance of survival into adulthood. Men are attracted to young fertile healthy women as any mating/relationship will produce the most offspring.
Bottom line you do you and get your freak on, as long as he treats you with respect and the relationship is not dysfunctional. Aside from age if everything is good then go for it.